Cluster 2: Nanohybrid Characterization and New Sensing Principles

Participants focus on discovery and development of new sensing and separation principles made possible by the unique anisotropic properties of the nanohybrids, as well as by the development of suitable instrumentation to monitor molecular interactions at the surface of the 3-D nanostructures.

Cluster 2 Research Focii:



Surface-enhanced optical anisotropy.

The objective of this research is to develop experimental approaches to accurately measure the changes in the anisotropic optical properties of highly-porous ultra-thin films composed of highly-coherent and highly-ordered 3-D nanostructures upon adsorption, desorption and/or reconfiguration of individual organic molecules within or onto the surfaces of the 3-D nanostructures. A related objective is to modify and design 3-D nanostructures for improvement of sensitivity to target molecules and their properties.

Keywords: Highly porous thin films; Form-induced birefringence and dichroism; Generalized spectroscopic ellipsometry; Effective medium approximations; Microscopic dielectric polarizability models; Molecular adsorption, desorption and reconfiguration.


Surface-enhanced electrochemistry.

The objective of this research is to develop experimental approaches to accurately measure the changes in the electrochemical properties of highly-porous ultra-thin films composed of highly-coherent and highly-ordered 3-D nanostructures upon adsorption, desorption and/or reconfiguration of individual, electrochemically active organic molecules. A related objective is to modify and design 3-D nanostructures for improvement of sensitivity to target molecules and their properties.

Keywords: Nanostructured materials in electrochemistry; Nano-Electrochemistry; Electrochemical sensors; Folding-based electrochemical sensors.


Molecular target detection by combinatorial surface-acoustic, surface-optic and surface-impedance measurements.

The objective of this research is to increase sensitivity and selectivity for detection of target molecules using combinatorial approaches based upon unique anisotropic physical, optical and electrochemical properties of highly-ordered 3-D nanostructures.

Keywords: Quartz-Crystal-Microbalance with Dissipation, Generalized Ellipsometry, Electrochemistry, Combinatorial techniques; Surface-acoustic properties; Surface-optical properties; Surface-capacitance properties.

 

Cluster 2 Recent Research Highlights:

Combined QCM-D/GE as a tool to characterize stimuli-responsive swelling of and protein adsorption on polymer brushes grafted onto 3D-nanostructures.
Dynamic Analysis of DNA Nanoparticle Immobilization to Model Biomaterial Substrates using Combinatorial Spectroscopic Ellipsometry and Quartz Crystal Microbalance with Dissipation.
Insitu-Synthesis of Palladium Nanoparticles in Polymer Brushes followed by QCM-D coupled with spectroscopic ellipsometry.
Vector Magneto-Optical Generalized Ellipsometry for Sculptured Thin Films.
Generalized ellipsometry in-situ quantification of organic adsorbate attachment within slanted columnar thin films.
Combined Optical and Acoustical Method for Determination of Thickness and Porosity of Tranparent Organic Layers Below the Ultra-thin Film Limit.
Protein adsorption on and swelling of polyelectrolyte brushes: a simultaneous ellipsometry-quartz crystal microbalance study.
An integrated mid-infrared, far-infrared and terahertz optical Hall effect instrument (Invited Review).


Cluster 2 Researchers

Mathias Schubert - Generalized Ellipsometry; Imaging; Anisotropic materials. Tino Hofmann - Optical instrumentation design; THz Ellipsometry. Yuri Lyubchenko - Imaging of biopolymer nanoassemblies; AFM force spectroscopy. Rebecca Lai -  Electrochemical sensors. Angela Pannier -  Confocal and Fluorescence Microscopy.  David Hage - Chromatography and electro-chromatography.  Yusong Li - Engineered nanoparticles. Shannon Bartelt-Hunt - Prion folding and propagation.